| 3do | lr-4do | .iso | panafz10.bin | 1993: Panasonic |  |
| Amiga | UAE4ARM,UAE4ALL2 | .adf .adz .dms .exe .rp9 .zip | kick13.rom, kick20.rom, kick31.rom | 1985: Commodore |  |
| Amstrad CPC | lr-cap32, CapriceRPI | .cpc .dsk | – | 1984: Amstrad |  |
| Apple II | Linapple | .dsk | – | 1977: Apple |  |
| Atari 2600 | lr-stella, Stella | .7z .a26 .bin .gz .rom .zip | – | 1977: Atari |  |
| Atari 5200, 8-Bit Series | Atari800 | .a52 .atr .bas .bin .car .dcm .xex .xfd .atr.gz .xfd.gz | ATARIXL.ROM, ATARIBAS.ROM, ATARIOSA.ROM, ATARIOSB.ROM, 5200.rom | 1982: Atari |  |
| Atari 7800 | lr-prosystem | .7z .a78 .bin .zip | 7800 BIOS (U).rom | 1986: Atari |  |
| Atari Jaguar | lr-virtualjaguar | .j64 .jag | – | 1993: Atari |  |
| Atari Lynx | lr-handy, lr-beetle-lynx | .7z .lnx .zip | – | 1989: Atari |  |
| Atari ST, STE, TT, Falcon | Hatari | .ctr .img .ipf .raw .rom .st .stx | – | 1985: Atari |  |
| CoCo | XRoar | .asc .bas .cas .ccc .dmk .dsk .jvc .os9 .rom .sna .vdk .wav | bas13.rom | 1980: Tandy |  |
| Colecovision | lr-blueMSX, CoolCV | .bin .col .rom .zip | coleco.rom | 1982: Coleco |  |
| Commodore 64, VIC-20, PET | Vice | .crt .d64 .g64 .t64 .tap .x64 | – | 1982: Commodore |  |
| Dragon 32 | XRoar | .asc .bas .cas .ccc .dmk .dsk .jvc .os9 .rom .sna .vdk .wav | d32.rom | 1982: Dragon |  |
| Dreamcast | Reicast | .cdi .gdi | dc_boot.bin, dc_flash.bin | 1998: Sega |  |
| Famicom Disk System | lr-fceumm, lr-nestopia | .7z .fds .nes .zip | disksys.rom | 1986: Nintendo |  |
| FinalBurn Alpha | lr-fbalpha, lr-fbalpha2012, PiFBA | .7z .zip | isgsm.zip, neogeo.zip, nmk004.zip, pgm.zip, skns.zip, ym2608.zip | 2000: N/A |  |
| Genesis / Mega Drive | lr-genesis-plus-gx, lr-picodrive, DGEN | .7z .bin .gen .md .sg .smd .zip | – | 1988: Sega |  |
| Game Gear | lr-genesis-plus-gx,Osmose | .7z .bin .gg .sms .zip | – | 1990: Sega |  |
| Game Boy | lr-gambatte, lr-tgbdual | .7z .gb .zip | – | 1989: Nintendo |  |
| Game Boy Color | lr-gambatte, lr-tgbdual | .7z .gbc .zip | – | 1998: Nintendo |  |
| Game Boy Advance | lr-mgba, lr-vba-next, lr-gpSP, gpSP | .7z .gba .zip | gba_bios.bin | 2001: Nintendo | |
| Intellivision | jzIntv | .bin .int | exec.bin, grom.bin | 1979: Mattel |  |
| Macintosh | BasiliskII | .img .rom | disk.img, mac.rom | 1984: Apple |  |
| MAME | lr-mame2003, lr-mame2010,MAME4ALL-Pi,AdvanceMAME 1.4,AdvanceMAME 0.94,AdvanceMAME 3, lr-mame2014, lr-mame2016, lr-mame2000 | .zip | cpzn1.zip, cpzn2.zip, cvs.zip, decocass.zip, konamigx.zip, megaplay.zip, megatech.zip, neogeo.zip, nss.zip, pgm.zip, playch10.zip, skns.zip, stvbios.zip, taitofx1.zip, tps.zip | 1997: N/A | |
| Master System | lr-Genesis-Plus-GX, lr-picodrive, Osmose | .7z .bin .sms .zip | – | 1985: Sega |  |
| MSX | lr-bluemsx, lr-fmsx,OpenMSX | .col .dsk .mx1 .mx2 .rom | See Wiki Page | 1983: Microsoft |  |
| Neo Geo | lr-fbalpha, lr-fbalpha2012, PiFBA,GnGeo-Pi | .7z .zip | neogeo.zip | 1990: SNK |  |
| Neo Geo Pocket | lr-mednafen-ngp | .7z .ngp .zip | – | 1998: SNK |  |
| Neo Geo Pocket Color | lr-mednafen-ngp | .7z .ngc .zip | – | 1999: SNK |  |
| Nintendo 64 | Mupen64plus, lr-mupen64plus | .n64 .v64 .z64 | – | 1996: Nintendo |  |
| Nintendo DS | drastic, lr-desmume | .bin .nds | – | 2004: Nintendo |  |
| Nintendo Entertainment System | lr-fceumm, lr-nestopia,lr-quicknes | .7z .fds .fig .mgd .nes .sfc .smc .swc .zip | disksys.rom | 1983: Nintendo |  |
| Oric/Atmos | Oricutron | .dsk .tap | – | 1983: Tangerine Computer Systems |  |
| PC | DOSBox, rpix86 | .bat .com .exe .sh | – | 1981: IBM |  |
| PC-8800 | Quasi88 | .88d .cmt .d88 .t88 | FONT.ROM, N88.ROM, N88KNJ1.ROM, N88KNJ2.ROM, N88SUB.ROM | 1981: NEC |  |
| PC Engine / TurboGrafx-16 | lr-mednafen-pce-fast | .7z .ccd .chd .cue .pce .zip | syscard3.pce | 1987: NEC |  |
| PlayStation 1 | lr-pcsx-rearmed, pcsx-rearmed, lr-beetle-psx | .cbn .cue .img .iso .m3u .mdf .pbp .toc .z .znx | SCPH1001.BIN, scph5500.bin, scph5501.bin, scph5502.bin | 1994: Sony |  |
| PSP | lr-ppsspp, ppsspp | .cso .iso .pbp | – | 2004: Sony |  |
| ScummVM | ScummVM | See Wiki Page | – | 2001: N/A |  |
| Sega 32X | lr-picodrive | .32x .7z .bin .md .smd .zip | – | 1994: Sega |  |
| Sega CD | lr-genesis-plus-gx, lr-picodrive | .bin .chd .cue .iso | bios_CD_U.bin, bios_CD_E.bin, bios_CD_J.bin, us_scd1_9210.bin, eu_mcd1_9210.bin, jp_mcd1_9112.bin | 1991: Sega |  |
| Sega Saturn | lr-yabause, lr-beetle-saturn | .bin .cue .iso .mdf | saturn_bios.bin, sega_101.bin | 1994: Sega |  |
| Sega SG-1000 | lr-Genesis-Plus-GX | .7z .bin .sg .zip | – | 1983: Sega |  |
| Sharp X68000 | lr-px68k | .dim | cgrom.dat, iplrom.dat, iplrom30.dat, iplromco.dat, iplromxv.dat | 1987: Sharp |  |
| Super Nintendo Entertainment System | lr-snes9x2010, lr-snes9x, lr-snes9x2005, lr-snes9x2002, PiSNES,lr-armsnes, snes9x-rpi, | .7z .bin .fig .mgd .sfc .smc .swc .zip | – | 1990: Nintendo |  |
| TI-99/4A | ti99sim | .ctg | – | 1981: Texas Instruments |  |
| TRS-80 | sdltrs | .dsk | level2.rom | 1977: Tandy Corporation |  |
| Vectrex | lr-vecx | .7z .bin .gam .vec .zip | – | 1982: Milton Bradley |  |
| Videopac /Odyssey2 | lr-o2em | .bin | o2rom.bin | 1983: Philips |  |
| Virtual Boy | lr-beetle-vb | .7z .vb .zip | – | 1995: Nintendo |  |
| WonderSwan | lr-mednafen-wswan | .7z .ws .zip | – | 1999: Bandai |  |
| WonderSwan Color | lr-mednafen-wswan | .7z .wsc .zip | – | 2000: Bandai |  |
| Zmachine | Frotz | .dat .z1 .z2 .z3 .z4 .z5 .z6 .z7 .z8 .zip | – | 1979: Infocom | |
| ZX Spectrum | lr-fuse, Fuse, FBZX | .dsk .gz .img .mgt .scl .sna .szx .tap .trd .tzx .udi .z80 | – | 1982: Sinclair |  |
